STS-135 Liver Transcriptomics: Mouse Liver Gene Expression After Spaceflight

Mice were flown onboard the final Space Shuttle mission, STS-135, and their livers were collected for analysis within hours of landing. Samples were processed at the UCI Genomics High Throughput Facility, suggesting gene expression data. The dataset is provided by the National Aeronautics and Space Administration and was last updated in March 2026.

Use Cases

• Identify gene expression changes in liver tissue based on exposure to microgravity.
• Study mammalian stress response and adaptation based on the post-landing sample collection timeline.
• Analyze potential metabolic pathway alterations based on liver-specific transcriptomic data.

Strengths

• Data originates from a controlled NASA spaceflight mission (STS-135).
• Sample processing was standardized, with livers snap-frozen within 3-4 hours of landing.
• Analysis was conducted at a named high-throughput genomics facility (UCI Genomics High Throughput Facility).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The file format is listed as 'BIN', which may require specialized tools for access.

Provenance

Source

National Aeronautics and Space Administration

Collection Method

Mice were flown on STS-135, livers collected post-landing and snap-frozen, then analyzed via high-throughput genomics.

Time Range

Associated with the STS-135 mission (2011).

Freshness

Last updated 2026-03-13 19:20:44.557298; freshness should be verified.

Geography

Data collection likely involves spaceflight and terrestrial laboratory analysis.