Naphazoline and Antihistamine Analysis Data by Capillary Electrophoresis

A paper presents a capillary electrophoresis method for ultra-fast simultaneous determination of naphazoline with diphenhydramine, pheniramine, or chlorpheniramine. The method uses a 10 cm capillary column, achieving one analysis every 35 seconds with detection limits of 25 µmol L-1 for three compounds and 13 µmol L-1 for chlorpheniramine. Results were validated against high-performance liquid chromatography with no statistically significant differences at a 95% confidence level.

Use Cases

• Validating a rapid capillary electrophoresis method based on the described 35-second analysis time.
• Comparing analytical results to HPLC data based on the validation mentioned in the description.
• Assessing detection limits for naphazoline and antihistamines based on the reported 25 µmol L-1 and 13 µmol L-1 values.
• Optimizing background electrolyte conditions based on the specified 20 mmol L-1 histidine and 10 mmol L-1 3,4-dimethoxycinnamic acid composition.

Strengths

• Method achieves a high throughput of approximately 100 injections per hour.
• Reports specific detection limits: 25 µmol L-1 for NPZ, DIP, PHEN and 13 µmol L-1 for CPHEN.
• Validation against HPLC showed no statistically significant differences at a 95% confidence level.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Last update date is unknown; freshness unverified.

Provenance

Source

paperswithcode

Collection Method

Methodological data from a research paper describing a capillary electrophoresis procedure.