Chemotherapy Regimens and Tumor Mutation Burden in Advanced Colorectal Cancer

185.4 KB of genomic data supports research into how prior chemotherapy exposure influences mutational accumulation in advanced colorectal cancer. The dataset, created by Tomoya Sudo and last updated in April 2026, originates from a study published on figshare. It contains findings that tumor mutation burden should be interpreted with therapeutic history.

Use Cases

• Analyze the correlation between the number of prior chemotherapy regimens and tumor mutation burden (TMB) values.
• Investigate the genomic profiles of microsatellite stable (MSS) TMB-high cases to identify non-polymerase gene drivers.
• Assess whether elevated TMB values are predictive of sensitivity to immune checkpoint inhibitors in this patient cohort.
• Model the association between specific treatment exposures and patterns of mutational accumulation in tumor samples.

Strengths

• Data is directly linked to a published research study on a specific clinical-genomic association.
• Released under a permissive CC-BY-4.0 license, allowing for broad reuse and sharing.

Limitations

• The dataset is very small at 185.4 KB, indicating limited scope and likely a small sample size.
• Specific column names, row counts, and sample data are unavailable, hindering immediate usability assessment.
• Temporal and geographic coverage of the patient samples is not specified in the provided information.

Provenance

Source

figshare, authored by Tomoya Sudo.

Collection Method

Comprehensive genomic profiling of advanced colorectal cancer patient samples, as per the study description.

Freshness

Last updated on April 5, 2026, indicating recent maintenance.