Supplemental Material for Depp1 Obesity Study: Mouse Gastric RNA-seq and Metabolic Data

Supplemental tables and figures accompany a manuscript on the role of the Depp1 gene in metabolic adaptation. The materials include RNA-seq differential expression results from mouse gastric mucosa under calorie restriction, diet-induced obesity, and lean control conditions. Sheybani-Deloui, Sepideh authored this data, which was last updated on June 8, 2026.

Use Cases

• Identify differentially expressed genes based on RNA-seq results comparing calorie restriction, diet-induced obesity, and lean control conditions.
• Perform Gene Ontology enrichment analysis based on the provided biological-process enrichment results for regulated gene sets.
• Validate findings in human contexts based on correlation analyses with GHRL expression from a public human gastric single-cell RNA-seq dataset.
• Investigate sex-specific metabolic effects based on sex-stratified hepatic gene-expression analyses in Depp1-knockout mice.

Strengths

• Data supports a specific, peer-reviewed manuscript investigating Depp1's role in diet-induced obesity.
• Includes multi-condition comparisons (calorie restriction, diet-induced obesity, lean control) and cross-species validation with human data.
• Materials cover both transcriptomic (RNA-seq) and physiological (metabolic phenotyping) levels of analysis.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data freshness should be verified as the last update timestamp is in the future (2026-06-08).

Provenance

Source

Texas Data Repository Harvested Dataverse

Collection Method

Likely generated from laboratory experiments including RNA sequencing and metabolic phenotyping of genetically modified mice.

Freshness

Last updated 2026-06-08 04:10:10