Supplementary data: Evaluation of steroid toxicity using the Glucocorticoid Toxicity Index

Supplementary data for a 2026 peer-reviewed article in the Journal of Comparative Effectiveness Research. The dataset includes tables with definitions and Glucocorticoid Toxicity Index-Metabolic Domains (GTI-MD) scores for 682 adult patients with myasthenia gravis, categorized by steroid use. It was created by Glenn Phillips and shared on figshare.

Use Cases

• Benchmarking steroid toxicity scores based on patient steroid exposure frequency and strength.
• Analyzing the relationship between prednisone-equivalent dosage and cumulative worsening scores (CWS).
• Comparing metabolic domain toxicity between steroid-initiator and steroid-naive patient cohorts.
• Validating the GTI-MD instrument's sensitivity for detecting toxicity in large electronic health record datasets.

Strengths

• Data supports a peer-reviewed publication in the Journal of Comparative Effectiveness Research.
• Includes results for 682 patients, with 377 in the steroid-initiator cohort and 305 in the steroid-naive cohort.
• Reports specific statistical results, such as CWS scores of 22.6 ± 22.8 for the MG-SI cohort versus 18.7 ± 21.2 for the MG-SN cohort.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (24.7 KB), indicating limited scope, likely containing summary tables rather than patient-level records.

Provenance

Source

Optum electronic health records, as cited in the associated article.

Collection Method

Real-world data analysis assessing steroid toxicity using the GTI-MD algorithm on patient vital signs and laboratory tests.

Freshness

Last updated 2026-05-22 10:47:38; freshness should be verified.

Geography

United States