Supplementary File 1: 4-Methylcatechol Effects on Diabetic Myocardial Disorder

A 11.2 MB DOCX file authored by Zong-Hao Zhang details a study investigating the protective effects of 4-methylcatechol against diabetic myocardial injury. Bioinformatics analysis identified ESR1 as a core therapeutic target, and in vitro experiments validated the cardioprotection via the ESR1-PI3K-AKT signaling axis. The dataset was last updated on April 9, 2026.

Use Cases

• Analyze bioinformatics target identification methods based on the description of ESR1 discovery
• Validate molecular docking simulation results based on the described hydrogen bond interactions with ESR1 residues
• Study oxidative stress and apoptosis modulation pathways based on the KEGG/GO enrichment analyses mentioned
• Investigate in vitro cardiomyocyte injury models based on the described HG/PA-induced AC16 cell experiments

Strengths

• The dataset is openly licensed under CC-BY-4.0
• The description provides a detailed methodological narrative including bioinformatics, molecular docking, and in vitro validation
• The file size is 11.2 MB, suggesting substantial textual content

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The data is a single DOCX file; its internal structure and data format are not specified

Provenance

Source

figshare

Collection Method

Likely contains supplementary research data and textual analysis from a published study.

Freshness

Last updated 2026-04-09 04:07:37