Supplementary Data on 5-Methoxyresorcinol Effects in Osteoporosis Mouse Model

A research supplementary file authored by Maosheng Yang, uploaded on figshare in May 2026. The 2.4 MB document describes a study evaluating the therapeutic potential of 5-methoxyresorcinol for osteoporosis using network pharmacology and in vitro/in vivo experiments.

Use Cases

• Analyze potential drug targets for osteoporosis based on network pharmacology results identifying 50 overlapping targets.
• Study the effects of a compound on osteoclast differentiation based on in vitro dose-dependent suppression experiments.
• Evaluate bone microarchitecture improvements based on micro-CT analysis results from an ovariectomized mouse model.
• Investigate signaling pathway regulation in bone resorption based on described inhibition of the PI3K–AKT–GSK3β axis.
• Assess reactive oxygen species homeostasis in osteoclast function based on described reduction of RANKL-induced ROS generation.

Strengths

• The description provides specific quantitative results, including 107 potential targets of MR and 50 overlapping targets.
• Experimental details are given, such as MR concentrations ≤1 mM showing no significant cytotoxicity.
• The file is openly licensed under CC-BY-4.0.

Limitations

• The dataset is a single 2.4 MB DOCX file; the underlying data tables, column definitions, and row counts are unknown.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data may reflect the specific experimental bias inherent to the described mouse model study.

Provenance

Source

figshare

Collection Method

Likely contains supplementary data from a research study involving network pharmacology analysis, in vitro cell experiments, and in vivo mouse model evaluation.

Freshness

Last updated 2026-05-18 04:17:02; freshness should be verified.