Supplementary file 1_A pilot study of a novel portable mass spectrometer for rapid, simult

A pilot study comparing a novel portable mass spectrometer to HPLC-MS for detecting three anesthetic drugs in rat plasma. The portable MS enabled simultaneous quantitative analysis of etomidate, rocuronium bromide, and lidocaine within 4.5 minutes. The dataset, authored by Xiaoyu Xie and last updated in March 2026, includes regression equations and correlation results from the validation study.

Use Cases

• Validate portable mass spectrometry performance based on correlation results with HPLC-MS mentioned in the description.
• Model pharmacokinetic profiles based on plasma concentration data for etomidate, rocuronium, and lidocaine.
• Develop calibration algorithms for rapid drug detection based on the provided linear regression equations.
• Assess analytical method agreement for anesthetic drugs using the Bland-Altman analysis results described.

Strengths

• Data includes specific regression equations and R-squared values (e.g., 0.999 for lidocaine) for three anesthetic drugs.
• Results show strong Pearson correlations (e.g., r=0.9937 for lidocaine) between two analytical methods.
• Analysis was completed within a rapid 4.5-minute timeframe per sample.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (5.4 MB), suggesting a limited sample size.

Provenance

Source

Xiaoyu Xie via figshare.

Collection Method

Plasma samples from rats administered specific drug doses, analyzed by portable MS and compared with HPLC-MS.

Freshness

Last updated 2026-03-18 07:35:16; freshness should be verified.