Geraniin Effects on Ulcerative Colitis in Mice: Multi-Omics and In Vivo Analysis

A preclinical study investigating the natural compound geraniin in a DSS-induced murine model of ulcerative colitis. The research integrates multi-omics data from public transcriptomic and single-cell databases with in vivo experiments assessing disease activity, histopathology, and protein expression. The dataset, authored by Chang Cheng and last updated in May 2026, consists of a 1.1 MB DOCX file containing the supplementary materials for this analysis.

Use Cases

• Identify potential drug targets for inflammatory diseases based on integrated database screening and protein-protein interaction networks.
• Analyze macrophage and neutrophil subpopulation responses to treatment using single-cell RNA-seq data and AUCell scoring.
• Investigate associations between polyphenol treatment and inflammatory pathway modulation (e.g., IL-17, TNF signaling) through differential gene expression and enrichment analysis.
• Correlate in vivo disease activity index (DAI) scores and histopathological findings with molecular markers from Western blot and immunofluorescence data.

Strengths

• Integrates data from multiple public omics databases (GEO, CTD, SwissTargetPrediction) and in vivo experiments.
• Identifies a specific key subnetwork of 42 genes from an initial set of 27 geraniin targets and 337 UC-related genes.
• Includes results from three distinct mouse treatment groups (control, model, and two geraniin doses) for comparative analysis.

Limitations

• The dataset is a 1.1 MB DOCX document; the underlying raw or processed data tables are not provided as separate structured files.
• Column-level documentation is absent; field semantics must be inferred from the manuscript text after download.
• Row count is unknown, which may limit suitability assessment for computational reuse.

Provenance

Source

figshare

Collection Method

Integrated analysis of public transcriptomic/single-cell data and original in vivo experiments in a murine model.

Freshness

Last updated 2026-05-13 04:48:20