Mouse Hippocampal Neurogenesis and Memory Data After Kainic Acid-Induced Seizures

A 75.2 KB dataset from a 2026 figshare study by Diana López-Ibarra investigating the effects of acute hyperexcitability on adult hippocampal neurogenesis and memory in mice. The study administered low (5 mg/kg) or high (25 mg/kg) doses of kainic acid to mice, recorded EEG, assessed spatial and contextual fear memory, and analyzed adult-born granule cells 32 days post-treatment. Findings reveal seizure severity differentially modulates morphological and synaptic features of new neurons and selectively disrupts spatial memory.

Use Cases

• Modeling the relationship between seizure severity and neurogenesis features based on kainic acid dose levels.
• Analyzing correlations between EEG patterns and spatial memory impairment outcomes.
• Investigating morphological changes in adult-born granule cells based on dendritic spine density and presynaptic bouton data.

Strengths

• Data is associated with a peer-reviewed research methodology involving EEG recording and cellular analysis.
• Experimental design includes controlled variables such as specific kainic acid doses (5 mg/kg and 25 mg/kg) and a 32-day post-treatment analysis window.
• Dataset is openly licensed under CC-BY-4.0 for reuse.

Limitations

• The dataset is very small (75.2 KB), indicating limited scope or summary-level data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare, author Diana López-Ibarra.

Collection Method

Experimental data from a study administering kainic acid to mice, with subsequent EEG, memory assessment, and cellular analysis.

Freshness

Last updated 2026-06-02 04:28:40; freshness should be verified.