Advanced In Vitro NAMs for Chemical Mixture Toxicity Assessment, 2021-2025

A review covering 353 in vitro NAM-based studies published between 2021 and 2025, with 70 studies classified as advanced in vitro NAMs. The dataset, authored by Hyunwoo Kim and shared on figshare, analyzes the application of models like route-of-exposure-relevant systems, Omics, and 3D models to assess mixtures including air pollutants, PFAS, and pesticides.

Use Cases

• Analyze the distribution of advanced in vitro NAM categories (e.g., route-of-exposure models, Omics) used in mixture toxicity studies.
• Identify research trends and gaps for specific chemical mixture types like PFAS or pesticides based on the reviewed study corpus.
• Support regulatory translation assessments by examining how advanced in vitro NAMs address challenges like identifying toxicity drivers and non-additive responses.

Strengths

• Includes 70 advanced in vitro NAM-based studies identified through a structured PubMed literature search.
• Covers a defined time range of studies published between 2021 and 2025.
• Analyzes diverse chemical mixtures including air pollutants, PFAS, phthalates, and pesticides.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The 46.6 KB file size suggests a limited scope, likely containing summary or metadata rather than raw experimental data.

Provenance

Source

Hyunwoo Kim via figshare

Collection Method

Literature review based on a PubMed search.

Time Range

2021-2025

Freshness

Last updated 2026-05-28 22:03:18; freshness should be verified.