Mouse Model Data on Lactate and Cardiac Function After Myocardial Infarction
by Ze Chen·Updated 2mo ago
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Description
A 26.6 KB supplementary document from a study investigating lactate's role in cardiac dysfunction post-myocardial infarction. The research used NIH 3T3 fibroblasts and C57BL/6J mice, establishing four model groups (SED-SHAM, AE-SHAM, SED-MI, AE-MI). It was authored by Ze Chen, last updated on April 20, 2026, and shared under a CC-BY-4.0 license on figshare.
Use Cases
Analyzing the relationship between lactate levels and cardiac function metrics (LVEF, LVFS) based on the described mouse model experiments.
Investigating fibroblast activation markers (COL I, α-SMA) in response to lactate treatment based on the in vitro methodology.
Studying serum metabolite changes, such as arachidonoyl carnitine accumulation, mediated by lactate using the described metabolomics approach.
Evaluating the effect of aerobic exercise intervention on post-infarction lactate metabolism and heart function recovery based on the four-group experimental design.
Strengths
Provides experimental evidence linking lactate accumulation to cardiac dysfunction after myocardial infarction.
Includes data from both in vitro (fibroblast) and in vivo (mouse model) experiments across four distinct treatment groups.