Supplementary File 1: Age-Dependent Spatial Memory Interference in APP/PS1 Mice

Dejana Mitrovic Tartanoglu authored this supplementary document for a study on Alzheimer's disease pathology. The 6.3 MB DOCX file contains background, methods, results, and conclusions from an experiment using the Objects in Updated Locations paradigm to test spatial memory updating in APP/PS1 and wild-type mice. The dataset was last updated on June 2, 2026, and is shared under a CC-BY-4.0 license.

Use Cases

• Analyzing the relationship between amyloid pathology and spatial memory performance based on the described behavioral paradigm.
• Studying age-stratified vulnerability to memory interference based on the genotype effects reported in older animals.
• Investigating neuronal recruitment via cFos expression in relation to behavioral performance in mouse models.
• Benchmarking automated behavioral tracking pipelines against manual scoring for object exploration analysis.

Strengths

• Includes detailed methodological description of the Objects in Updated Locations paradigm for spatial memory testing.
• Contains results from age-stratified analyses, highlighting a significant genotype effect in older animals.
• Document is 6.3 MB, suggesting it contains substantial textual and potentially graphical content.

Limitations

• The core data (e.g., raw behavioral metrics, column-level data) is not directly accessible; the file is a supplementary document.
• Row count and data structure are unknown, limiting suitability assessment for direct computational analysis.
• Freshness should be verified as the last update date is in the future (2026-06-02).

Provenance

Source

Dejana Mitrovic Tartanoglu via figshare

Collection Method

Data likely originates from controlled laboratory experiments using APP/PS1 and wild-type mice, with automated behavioral tracking and cFos immunohistochemistry.

Freshness

Last updated 2026-06-02 05:42:00; freshness should be verified.