Plasma Exosomal Proteins in Intrahepatic Cholestasis of Pregnancy

SWATH proteomics identified 109 and 46 differentially expressed proteins in plasma exosomes from pregnant women with intrahepatic cholestasis. The dataset likely contains quantitative protein profiles from 35 pregnant women, including 10 with moderate ICP, 10 with severe ICP, and 15 healthy controls. Author Yuxuan Jiang published the data on figshare under a CC-BY-4.0 license in April 2026.

Use Cases

• Identify diagnostic biomarkers for intrahepatic cholestasis of pregnancy based on differentially expressed proteins.
• Analyze complement activation and blood coagulation pathways in pregnancy disorders based on bioinformatics results.
• Validate candidate hub proteins like HRG, VWF, and PIGR for disease pathogenesis based on Western blot verification.
• Compare protein expression profiles between total exosomes and placenta-derived exosomes based on the two comparison groups.

Strengths

• Includes proteomic data from 35 patient samples, providing a defined cohort size.
• Identifies 109 and 46 differentially expressed proteins, offering a specific quantitative result.
• Data is published under a CC-BY-4.0 license, allowing for open reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is 10.0 MB, which is a small scale for proteomic data.

Provenance

Source

figshare

Collection Method

Sequential window acquisition of all theoretical fragment ions (SWATH) proteomics performed on plasma exosomes.

Freshness

Last updated 2026-04-10 06:00:55; freshness should be verified.