Anti-β2GPI IgG Domain Reactivity in APS Cohorts

296 serum samples from the APS ACTION (n=191) and an Italian validation (n=105) cohort were analyzed for anti-β2GPI IgG domain reactivity. The dataset, authored by Claudia Grossi and last updated in 2026, includes results from chemiluminescence, ELISA, and fluorescence enzyme immunoassays. It investigates the binding of antibodies to different β2GPI domains (DI-DV) and its impact on diagnostic assay discordance.

Use Cases

• Compare diagnostic assay performance based on anti-β2GPI IgG domain reactivity profiles.
• Investigate the clinical relevance of antibodies targeting β2GPI domains beyond domain I.
• Analyze cohort characteristics associated with anti-DI/anti-DIV/DV double-negative or single-positive antibody status.

Strengths

• Includes 296 samples from two distinct clinical cohorts.
• Compares results from four different immunoassay methods.
• Analyzes reactivity against five specific β2GPI domains using recombinant variants.

Limitations

• Row count and column-level documentation are unknown, requiring manual inspection after download.
• The dataset is small (261 KB), indicating limited scope.

Provenance

Source

figshare, authored by Claudia Grossi.

Collection Method

Serum analysis using chemiluminescence (CLIA), in-house ELISA, commercial ELISA, and fluorescence enzyme immunoassay.

Freshness

Last updated 2026-05-01 05:24:50.

Geography

Data from international (APS ACTION) and Italian multi-center cohorts.