Meta-Analysis of Salidroside Effects in Diabetic Nephropathy Animal Models

Di Sun's systematic review and meta-analysis synthesizes results from 14 preclinical studies involving 257 animals, investigating the renoprotective effects of salidroside in diabetic nephropathy models. The analysis, conducted according to PRISMA 2020 guidelines, was uploaded to figshare on 2026-04-10. It includes pooled estimates for outcomes like serum creatinine, blood urea nitrogen, and kidney index.

Use Cases

• Assess the pooled effect size of salidroside on renal function markers like serum creatinine and blood urea nitrogen.
• Evaluate the compound's impact on oxidative stress and inflammatory mediators based on the meta-analysis results.
• Analyze methodological heterogeneity and potential bias across included preclinical studies.
• Inform the design of future rigorous, pre-registered animal trials based on identified evidence gaps.

Strengths

• Follows PRISMA 2020 guidelines for systematic review reporting.
• Includes quantitative meta-analysis results with Hedges' g effect sizes and confidence intervals.
• Assesses risk of bias using the SYRCLE tool for animal studies.

Limitations

• The primary data file is a DOCX document (8.3 MB); column-level documentation and raw data are absent.
• Interpretation is constrained by high heterogeneity and possible small-study or publication effects as noted in the conclusion.
• Row count and structured data format are unknown, limiting suitability assessment for computational analysis.

Provenance

Source

Di Sun via figshare.

Collection Method

Systematic literature review and meta-analysis of preclinical studies from multiple databases.

Time Range

Literature search covered from database inception to 24 November 2025.

Freshness

Last updated 2026-04-10 05:29:22.

Geography

Studies likely include international research, though specific geography is not stated.