Mouse Brain Metabolomic and Lipidomic Profiles Across Menopause by APOE Genotype

Supplementary file 1 from a study investigating the impact of APOE genotype on brain metabolism during menopause. The dataset contains metabolomic and lipidomic profiles from humanized female APOE3/3, APOE3/4, and APOE4/4 mice across pre- to postmenopausal stages. It was authored by Tian Wang and last updated on June 2, 2026.

Use Cases

• Modeling the relationship between APOE genotype and brain metabolic adaptation during menopause based on the described metabolomic and lipidomic profiles.
• Investigating the mechanistic basis for increased Alzheimer's disease susceptibility in APOE4-positive women using the provided mouse model data.
• Analyzing the impact of a single vs. double APOE4 allele on postmenopausal amino acid depletion and TCA cycle intermediates as described in the results.

Strengths

• Data is derived from a controlled study using humanized mouse models with specific APOE genotypes (APOE3/3, APOE3/4, APOE4/4).
• Profiling covers multiple biological stages (chronological and endocrinological from pre- to postmenopause).
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• The dataset is very small (21.2 KB), suggesting it is likely a summary or supplementary document rather than the full raw data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale analysis.

Provenance

Source

figshare, author Tian Wang.

Collection Method

Brain metabolomic and lipidomic profiling conducted on humanized female mice.

Freshness

Last updated 2026-06-02 05:42:37; freshness should be verified.