Supplementary File 1: ARMC2 Loss Effects on Cilia in Mouse Organs

A PDF document authored by Elsa Giordani, last updated on 2026-05-26, presents research on the ARMC2 gene. The study investigates how ARMC2 deficiency in mice leads to cilia structure and function impairments, resulting in symptoms of primary ciliary dyskinesia across multiple organs.

Use Cases

• Study the role of ARMC2 in cilia formation based on observations in trachea and oviduct.
• Investigate the link between ciliary beating defects and mucus accumulation described in the mouse model.
• Analyze the correlation between ARMC2 mutations and reproductive outcomes based on the finding of fewer pups in mutant females.
• Examine potential neurological manifestations of ciliopathies based on observations of enlarged brain ventricles and hydrocephalus.

Strengths

• The dataset is a detailed research document with a specific focus on the ARMC2 gene and its phenotypic effects.
• It is published under a permissive CC-BY-4.0 license, allowing for wide reuse.

Limitations

• The dataset is a single 682.9 KB PDF file; its scope is limited to the described research findings.
• Column-level documentation is absent; field semantics must be inferred from the text.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Research findings from a mouse model study.

Freshness

Last updated 2026-05-26 06:01:52; freshness should be verified.