Mouse Gut Microbiota and Gene Expression Data from Multigenerational Sweetener Study

Supplementary file 1 from a figshare study by Francisca Concha Celume, last updated April 2026. The dataset likely contains results from a mouse study comparing the effects of parental sucralose or stevia consumption on fecal microbiota, short-chain fatty acids, and gene expression across three generations (F0, F1, F2). The file is 1.3 MB and is provided in DOCX format under a CC-BY-4.0 license.

Use Cases

• Analyze changes in fecal microbiota composition based on sweetener exposure mentioned in the description
• Compare short-chain fatty acid concentrations across treatment groups and generations described in the study
• Investigate gene expression patterns for Tlr4, Tnf, Tjp1, and Srebp1 in liver and intestine tissues
• Model the transmission of metabolic traits from F0 to F1 and F2 generations as outlined in the methods

Strengths

• Data covers three mouse generations (F0, F1, F2), allowing longitudinal analysis
• Includes multiple biological endpoints: microbiota, SCFAs, and gene expression
• Study design compares two distinct non-nutritive sweeteners (sucralose and stevia) against a control

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The primary data is embedded in a DOCX document, which may require extraction and formatting

Provenance

Source

figshare

Collection Method

Experimental study with 47 mice divided into three treatment groups over 16 weeks

Freshness

Last updated 2026-04-10 06:03:28