Aspirin and Sepsis Outcomes in Atrial Fibrillation Patients from MIMIC-IV and eICU-CRD

8,827 patients with sepsis and atrial fibrillation were analyzed from the MIMIC-IV database, with external validation in eICU-CRD. The retrospective cohort study by Fangchao Chen, last updated in May 2026, investigates the association between early aspirin exposure and mortality. Results show early aspirin exposure was associated with a lower 30-day all-cause mortality hazard ratio of 0.624 in the fully adjusted model.

Use Cases

• Assessing the association between early aspirin use and mortality based on patient classification by exposure timing.
• Validating clinical findings across different ICU databases based on the use of MIMIC-IV and eICU-CRD.
• Conducting subgroup analyses on sepsis patients with atrial fibrillation based on the described cohort.
• Performing weighted sensitivity analyses for observational studies based on the described overlap-weighted method.

Strengths

• Analysis includes 8,827 patients with sepsis and atrial fibrillation from the MIMIC-IV database.
• External validation was performed using the separate eICU-CRD database.
• Multiple analytical methods were used, including Kaplan–Meier analysis, multivariable Cox regression, and weighted sensitivity analyses.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the underlying data files is unknown, which may limit suitability assessment.
• The primary data file is a 205.8 KB DOCX document, suggesting limited raw data scope.

Provenance

Source

MIMIC-IV and eICU-CRD databases

Collection Method

Retrospective cohort study

Freshness

Last updated 2026-05-26 04:37:22; freshness should be verified.