Meta-Analysis of Leukotriene Receptor Antagonists and Neuropsychiatric Risk by Age Group

A systematic review and meta-analysis by Jiawen Xian, uploaded to figshare in 2026, evaluating the association between leukotriene receptor antagonists (LTRAs) and neuropsychiatric disorders. The analysis includes 21 studies from databases like PubMed and Embase, with results indicating an age-dependent risk profile. Findings suggest a favorable safety profile in pediatric populations but an increased risk in adults.

Use Cases

• Conducting secondary analysis of drug safety signals based on aggregated relative risk data from 21 studies.
• Investigating age-dependent pharmacological risk profiles based on subgroup analysis results for pediatric and adult populations.
• Validating meta-analytic methodologies using the reported statistical measures like relative risk, confidence intervals, and I² heterogeneity.
• Informing clinical guideline development for LTRA prescription based on the synthesized evidence of neuropsychiatric risk.

Strengths

• Includes 21 studies aggregated from multiple databases (PubMed, Embase, Web of Science, Cochrane Library) up to April 2025.
• Provides specific statistical results, including relative risk (RR) and 95% confidence intervals for overall and age-stratified analyses.
• Documents a systematic review protocol registration (CRD420251042206) and uses established quality assessment (Newcastle-Ottawa Scale).

Limitations

• The primary data file is a 2.1 MB DOCX document; the underlying tabular data (e.g., study-level data) is not directly accessible in a structured format.
• Row count and column-level documentation for any underlying data are unknown, limiting suitability assessment for computational analysis.
• Description metadata is limited; actual data quality and structure require manual inspection after download.

Provenance

Source

Jiawen Xian via figshare.

Collection Method

Systematic literature review and meta-analysis of existing studies.

Time Range

Studies from database inception until 28 April 2025.

Freshness

Last updated 2026-04-30 05:23:59; freshness should be verified.