Platelet-to-Neutrophil Ratio and Asthma-COPD Overlap in a Chinese Cohort

A cross-sectional study of 1,025 participants, including 340 with asthma-COPD overlap (ACO), 348 with asthma, 372 with COPD, and 685 healthy controls. The dataset, authored by Lei Yang and last updated in March 2026, examines the association between the platelet-to-neutrophil ratio (PNR) and ACO risk using multivariable logistic regression and restricted cubic spline models.

Use Cases

• Train a classification model to predict ACO risk based on PNR and covariates like age, sex, and BMI.
• Analyze non-linear dose-response relationships between a blood cell ratio and disease risk using the reported threshold of 61.17.
• Conduct subgroup analyses to investigate potential differences in biomarker associations across specific population groups.
• Validate the reported discriminatory performance (AUC 0.774) of PNR as a biomarker for ACO in an independent cohort.

Strengths

• Includes data from 1,025 participants, providing a substantial sample for analysis.
• Reports a statistically significant inverse association (OR=0.964) between PNR and ACO, adjusted for 12 key covariates.
• Identifies a specific PNR threshold of 61.17 for a non-linear relationship with ACO risk.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• Data may reflect geographic bias inherent to the single-country, cross-sectional study design.
• The dataset is small in scale at 80.3 KB, indicating limited scope.

Provenance

Source

figshare, author Lei Yang.

Collection Method

Cross-sectional retrospective study using clinical data.

Freshness

Last updated 2026-03-18 07:07:56; freshness should be verified.

Geography

China