Supplementary file 1_Association between vitamin D levels and psychological stress-induced

2165 adults with asthma and 2331 with psychological stress-induced asthma (PSA) were analyzed from NHANES cycles 2007–2012 and 2015–2018. This research by Zhijie Zhang, last updated in April 2026, integrates cross-sectional NHANES data with a prospective cohort study using untargeted metabolomics. Findings suggest higher vitamin D levels are independently associated with a lower incidence of PSA, particularly depression-dominant cases.

Use Cases

• Investigating the non-linear relationship between vitamin D levels and asthma prevalence based on logistic regression and restricted cubic spline modeling described.
• Validating epidemiological findings from large public health surveys like NHANES with external metabolomics cohort data as outlined in the methods.
• Conducting subgroup analyses to explore associations within specific demographic or clinical populations referenced in the study.
• Building predictive models for psychological stress-induced asthma risk using vitamin D intake and circulating levels as potential features.

Strengths

• Analysis includes data from 4496 total participants (2165 with asthma, 2331 with PSA) sourced from the authoritative NHANES database.
• Study design integrates two methodologies: a cross-sectional analysis and a prospective cohort study with untargeted metabolomics for external validation.
• Results include specific statistical measures, such as an OR of 0.9967 for the association between vitamin D and PSA incidence.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the underlying analytical dataset is unknown, which may limit suitability assessment.
• The primary data file is a 150.2 KB DOCX document, which suggests the dataset scale is limited and may contain summarized results rather than raw data.

Provenance

Source

National Health and Nutrition Examination Survey (NHANES) and an external Chinese cohort.

Collection Method

Cross-sectional analysis combined with a prospective cohort study using untargeted metabolomics.

Time Range

NHANES cycles 2007–2012 and 2015–2018.

Freshness

Last updated 2026-04-22 05:35:17; freshness should be verified.

Geography

United States (NHANES) and China (external validation cohort).