FCRL3 Gene Variants and Rheumatoid Arthritis Risk in an Indian Population

An Indian case-control study of 226 rheumatoid arthritis patients and 239 controls, investigating the association of four FCRL3 gene variants with disease susceptibility. The dataset includes genotyping results for SNPs rs7522061, rs11264799, rs11264797, and rs7549100, validated by Sanger sequencing, and results from in silico molecular docking and dynamics simulations. The data was authored by Mohamed Muzammil S and last updated on June 3, 2026.

Use Cases

• Assessing genetic risk associations for rheumatoid arthritis based on FCRL3 SNP genotypes.
• Performing gender-stratified or age-and-sex-adjusted analyses of genetic susceptibility.
• Validating in silico molecular docking predictions (e.g., HADDOCK scores) with clinical genotype data.
• Comparing the structural stability of wild-type versus variant FCRL3 proteins based on molecular dynamics simulation metrics.

Strengths

• Includes data from 465 total participants (226 cases, 239 controls).
• Genotyping results were validated using Sanger sequencing.
• Analysis includes both statistical association tests (ORs, CI, logistic regression) and computational structural biology results.
• Released under a CC-BY-4.0 license for open reuse.

Limitations

• The dataset is very small at 14.2 KB, indicating limited scope.
• Row count and column-level documentation are unknown; field semantics must be inferred after download.
• Data may reflect geographic bias inherent to the specific Indian population sample.

Provenance

Source

figshare

Collection Method

Genotyping via High-Resolution Melting Analysis and Sanger sequencing, with in silico homology modelling, molecular docking, and coarse-grained molecular dynamics simulations.

Freshness

Last updated 2026-06-03 08:04:32; freshness should be verified.

Geography

India