Prenatal Parabens Exposure and Pregnancy Outcomes in a Chinese Cohort

A prospective cohort of 934 mother-infant pairs from Ningxia, China, analyzed for associations between prenatal exposure to five parabens and adverse pregnancy outcomes. The dataset includes maternal serum paraben concentrations measured by HPLC-MS/MS, depressive symptom scores from the Edinburgh Postnatal Depression Scale, and clinical outcomes like fetal distress and macrosomia. It was authored by Mengjun Chang and last updated on 2026-04-23.

Use Cases

• Modeling individual and mixture effects of parabens on adverse pregnancy outcomes based on serum concentration data.
• Investigating effect modification of environmental exposures by maternal depressive symptoms using stratified interaction analyses.
• Identifying primary chemical contributors to mixture effects on outcomes like macrosomia using quantile g-computation methods.

Strengths

• Includes data from 934 mother-infant pairs, providing a substantial sample size for analysis.
• Measures five specific parabens (e.g., propylparaben, ethylparaben) using HPLC-MS/MS, a precise analytical method.
• Integrates clinical pregnancy outcomes with validated mental health assessment (Edinburgh Postnatal Depression Scale).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for certain modeling tasks.
• Data may reflect geographic bias inherent to the single cohort from Ningxia, China.

Provenance

Source

figshare

Collection Method

Prospective cohort study with serum analysis and survey assessment.

Freshness

Last updated 2026-04-23 05:34:48; freshness should be verified.

Geography

Ningxia, China