Supplementary Data on Azoxystrobin's Molecular Mechanism in Oral Leukoplakia

A 1.2 MB PDF file authored by Wenjing Li, last updated on 2026-04-20. The file contains supplementary data for a study investigating how the fungicide Azoxystrobin binds to specific sites on the Peroxiredoxin 1 protein to induce mitochondrial dysfunction and apoptosis in oral leukoplakia cell lines.

Use Cases

• Validate molecular docking predictions based on the described AZOX-Prx1 interaction sites.
• Analyze mitochondrial apoptosis pathway activation based on the described Bax/Bcl-2 ratio and Cytochrome C release.
• Study mitochondrial dysfunction markers based on the described complex III activity, ROS production, and membrane potential data.
• Compare drug effects across genetic variants based on the described Prx1-WT, Trp87, and Thr90 mutant cell lines.

Strengths

• Data is associated with a detailed experimental methodology described in the PDF.
• The study focuses on a specific molecular mechanism with defined protein target sites.
• License is CC-BY-4.0, permitting open sharing and adaptation.

Limitations

• The dataset is a single 1.2 MB PDF file; the underlying raw data format and structure are unknown.
• Column-level documentation is absent; field semantics must be inferred from the article.
• Row count is unknown, which may limit suitability assessment for computational analysis.

Provenance

Source

figshare, author Wenjing Li

Collection Method

Experimental data from cell culture assays, molecular docking, and protein analysis as described.

Time Range

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Freshness

Last updated 2026-04-20 04:11:43; freshness should be verified.

Geography

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