Rat Study Data on Zingiber Mioga for Constipation via Metabolomics and Metagenomics

Supplementary file 1 from a study by Yutao Du, uploaded to figshare on 2026-03-18. The dataset contains results from an animal model experiment investigating the effects of Zingiber mioga on slow transit constipation. It includes quantified serum hormone levels, histopathological evaluations, and untargeted metabolomic and metagenomic analyses from 36 Sprague-Dawley rats.

Use Cases

• Identify differential metabolites associated with constipation treatment based on the 15 metabolites mentioned in the description
• Analyze shifts in gut microbial composition based on the reported changes in Eubacteriales/Lachnospirales ratio and beneficial genera
• Model dose-response relationships for a traditional medicine based on the low, medium, and high-dose intervention groups
• Correlate gastrointestinal hormone levels (SP, MTL, GAS) with histological and motility outcomes

Strengths

• Data is derived from a controlled animal study with six distinct treatment groups (n=6 per group)
• Analysis integrates two omics approaches: untargeted serum metabolomics and fecal metagenomics
• Includes quantified measurements for three key gastrointestinal motility regulators (SP, MTL, GAS)

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The dataset is a 288.1 KB PDF file, which suggests it may contain summary results rather than raw, high-volume data tables

Provenance

Source

Yutao Du via figshare

Collection Method

Experimental data from a rat model study with loperamide-induced slow transit constipation, followed by drug intervention and multi-omics analysis.

Time Range

Experimental period involved 35 consecutive days of model induction and concurrent intervention.

Freshness

Last updated 2026-03-18 07:39:37; freshness should be verified

Geography

Laboratory study; geographic origin of the data is not specified.