Supplementary file 1_Bioinformatics-driven insights: rapamycin-mediated CaMK2D inhibition

A 143.1 KB PDF file from figshare, authored by Ruxiang Sheng and last updated in May 2026. This supplementary file contains bioinformatics analysis supporting a study on rapamycin's therapeutic mechanism in intestinal ischemia-reperfusion injury. The analysis includes RNA-Seq data, differential gene expression, protein interaction networks, and molecular docking studies.

Use Cases

• Analyze differential gene expression patterns from RNA-Seq data mentioned in the description
• Study protein-protein interaction networks related to CaMK2D signaling pathways
• Validate molecular docking predictions between rapamycin and CaMK2D
• Correlate bioinformatics findings with cellular assay results like qRT-PCR and western blotting

Strengths

• File size is precisely 143.1 KB, indicating a focused supplementary document
• Includes results from multiple experimental models (cellular OGD/R and murine I/R) and bioinformatic techniques
• Released under the permissive CC-BY-4.0 license for reuse

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment
• Data is contained within a PDF, requiring extraction for computational analysis
• Description metadata is limited; actual data quality requires manual inspection after download

Provenance

Source

figshare, author Ruxiang Sheng

Collection Method

Bioinformatic analysis of RNA-Seq data from cellular and murine models of intestinal ischemia-reperfusion injury

Time Range

Study period not specified; file updated 2026-05-01

Freshness

Last updated 2026-05-01 04:19:06; freshness should be verified

Geography

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