Supplementary file 1_Biomarker-based clustering identifies distinct pulmonary function tra

A retrospective analysis of prospectively collected data from 92 patients with early severe systemic sclerosis (SSc) enrolled in a multicenter cohort. Serum levels of five chemokines and four soluble adhesion molecules were quantified at baseline, and patients were classified into three biomarker clusters. The dataset, authored by Saori Uesugi-Uchida and last updated in April 2026, compares pulmonary function trajectories among these clusters over time.

Use Cases

• Clustering patients into biologically distinct subgroups based on serum chemokine and adhesion molecule profiles.
• Identifying biomarker patterns associated with divergent pulmonary function trajectories, such as early or progressive decline in vital capacity.
• Developing early risk stratification models for interstitial lung disease in systemic sclerosis using biomarker-defined profiles.
• Validating the association between specific biomarker clusters (e.g., vasculopathic–fibrotic or inflammatory–vascular) and clinical outcomes.

Strengths

• Includes data from 92 patients with early severe systemic sclerosis, providing a focused clinical cohort.
• Quantifies nine specific biomarkers (five chemokines and four adhesion molecules) at baseline.
• Longitudinal pulmonary function data (percent vital capacity) is tracked for comparison among clusters.
• Published under a permissive CC-BY-4.0 license, allowing for reuse and redistribution.

Limitations

• Row count is unknown, which may limit suitability assessment for certain modeling tasks.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small in scale (98.5 KB), indicating limited scope and sample size.

Provenance

Source

figshare

Collection Method

Retrospective analysis of prospectively collected data from a multicenter cohort.

Time Range

The temporal coverage of the underlying patient data is not specified.

Freshness

Last updated 2026-04-20 05:23:41; freshness should be verified.

Geography

The geographic coverage of the multicenter cohort is not specified.