Biomimetic Core-Shell Nanofibrous Scaffolds with Organic Montmorillonite Interlayer

Electrospun polymer nanofibrous scaffolds mimic the extracellular matrix for biomedical applications. The study develops core-shell scaffolds of glycidyl methacrylate-grafted silk fibroin and poly(L-lactide-co-caprolactone) with an organically modified montmorillonite interlayer. These scaffolds exhibit potent antibacterial activity (>99% inhibition), strong anti-biofilm performance (>75% suppression), and long-lasting effects while maintaining cytocompatibility.

Use Cases

• Developing tissue engineering scaffolds based on tunable degradation kinetics facilitated by OMMT content.
• Engineering antibacterial biomaterials based on the >99% inhibition against Staphylococcus aureus.
• Designing anti-biofilm materials based on the >75% suppression performance.
• Studying the relationship between scaffold hydrophilicity, mechanical robustness, and water penetration based on the OMMT interlayer.

Strengths

• Scaffolds demonstrate potent antibacterial activity with >99% inhibition against Staphylococcus aureus.
• Strong anti-biofilm performance with >75% suppression.
• Scaffold properties such as hydrophilicity, mechanical robustness, and degradation kinetics are tunable via OMMT content.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect experimental bias inherent to the single study described.

Provenance

Source

Xiangrui Mao

Collection Method

Experimental study developing and characterizing core-shell nanofibrous scaffolds.

Freshness

Last updated 2026-05-14 05:23:53; freshness should be verified.