Supplementary file 1_Body mass index adjusted aspirin dosing does not overcome pharmacokin

35 pregnant women at high-risk for preeclampsia from a hospital in Istanbul, Türkiye, were stratified by BMI to assess aspirin dosing. The dataset includes blood salicylate levels, 11-dehydrothromboxane B2 levels, and uterine artery Doppler measurements taken at two time points during pregnancy. It was authored by Fulya Sultan Karaduman and shared on figshare under a CC-BY-4.0 license.

Use Cases

• Analyze the correlation between BMI and serum salicylate levels based on the reported inverse relationship (r = −0.648).
• Compare pharmacodynamic response (11-dTxB2 levels) between standard and BMI-adjusted aspirin dosing groups.
• Investigate predictors of diastolic notch resolution based on uterine artery resistance index changes.
• Perform mediation analysis to explore the role of salicylate levels in the relationship between BMI and uterine artery resistance.

Strengths

• Includes paired measurements (baseline and follow-up) for multiple biomarkers and clinical assessments.
• Provides specific pharmacokinetic results, such as a 17% lower serum salicylate level in the obese group despite a 50% higher aspirin dose.
• Dataset is openly available under a permissive CC-BY-4.0 license.

Limitations

• Small cohort size of 35 participants limits statistical power and generalizability.
• Non-randomized study design (prospective cohort) introduces potential for confounding.
• Column-level documentation is absent; field semantics must be inferred after download.

Provenance

Source

Haseki Training and Research Hospital, Istanbul, Türkiye.

Collection Method

Prospective cohort study with non-randomized stratification by BMI.

Time Range

Measurements taken between weeks 12–16 and 16–20 of pregnancy.

Freshness

Last updated 2026-05-29 06:17:35; freshness should be verified.

Geography

Istanbul, Türkiye.