Bulky PP1 Analogs: Cellular Effects on Non-Tumoral and Tumoral Cell Lines

Coralie Gicquel's dataset on figshare, last updated April 2026, examines the cellular effects of five bulky PP1 analog inhibitors. The 3.0 MB dataset likely contains results from experiments measuring migration, invasion, proliferation, cell cycle, viability, and differentiation in cell lines without engineered analog-sensitive kinases. The work provides data to caution against non-specific effects when using these inhibitors at concentrations ≥2 µM.

Use Cases

• Assessing the impact of 1NA-, 1NM-, and 3MB-PP1 on cell migration and invasion based on the described cellular processes.
• Evaluating the non-specific effects of PP1 analogs on cell proliferation and viability at concentrations ≥2 µM as mentioned in the description.
• Comparing the cellular specificity of 3IB- or 3MSB-PP1 to other analogs based on the described in vitro data predictions.

Strengths

• Dataset is licensed under CC-BY-4.0, permitting broad reuse with attribution.
• The description provides specific concentration thresholds (≥5 µM or 2 µM) for interpreting non-specific effects.
• Focuses on five specific bulky PP1 analogs (1NA-, 1NM-, 3MB-, 3IB-, 3MSB-PP1) as stated.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small at 3.0 MB, potentially limiting the scope of contained data.

Provenance

Source

Coralie Gicquel via figshare

Collection Method

Likely contains experimental results from cellular assays described in the associated research.

Freshness

Last updated 2026-04-28 10:21:05; freshness should be verified.