Cardiotoxicity Adverse Outcome Pathway Network with 64 Biological Events

A network of 64 biological events and 94 documented relationships mapping the mechanistic progression of chemical-induced heart toxicity. The dataset was created by Luiz Ladeira by integrating data from the OECD AOP-Wiki and was last updated on 2026-05-18. It is hosted on an interactive, FAIR-aligned web platform to support human-relevant, animal-free testing strategies.

Use Cases

• Identify critical biological crossroads for cardiotoxicity based on the network of 64 events and 94 relationships.
• Link biological events to specific laboratory assays using the provided methods catalogue.
• Model systemic contributions to heart damage based on described interactions with other organs like the kidneys.
• Prioritize impactful biomarkers for safety assessments based on the analysis of central drivers like oxidative stress.

Strengths

• Contains a defined network of 64 biological events and 94 relationships.
• Includes a methods catalogue linking biological events to specific laboratory assays.
• Hosted on an interactive, FAIR-aligned web platform for accessibility.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect the temporal and source bias inherent to the integrated OECD AOP-Wiki data.

Provenance

Source

figshare, author Luiz Ladeira.

Collection Method

Constructed by integrating data from the OECD AOP-Wiki.

Freshness

Last updated 2026-05-18 16:06:38; freshness should be verified.