Case Report on Anti-GBM Disease in Pregnancy with Sequential Biopsies and Novel Antibodies

A clinical case report details a rare instance of anti-glomerular basement membrane disease occurring during pregnancy. The report includes sequential kidney biopsy data showing lesion reduction and identifies novel circulating autoantibodies against type IV collagen and laminin-521. It was authored by Jing Zhuang and published on figshare under a CC-BY-4.0 license.

Use Cases

• Studying the clinical progression of anti-GBM disease based on sequential biopsy findings.
• Investigating novel autoantibody subtypes (anti-α1/α3(IV) and anti-LM521) and their association with disease phenotypes.
• Analyzing the impact of multidisciplinary management strategies, including plasma exchange and immunosuppression, on renal outcomes.
• Reviewing histological evidence for tissue repair following intensive immunotherapy and pregnancy termination.

Strengths

• Includes detailed histological evidence from sequential kidney biopsies.
• Reports a novel finding of dual anti-α1/α3(IV) and anti-LM521 antibodies in this context.
• Describes a comprehensive multidisciplinary treatment protocol.

Limitations

• Description metadata is limited; actual data quality requires manual inspection after download.
• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.

Provenance

Source

figshare

Collection Method

Clinical case report.

Freshness

Last updated 2026-06-01 05:18:23; freshness should be verified.