Supplementary file 1_Case Report: Compromised response of memory-formed bystander T cells

A single-patient case report details the characteristics of memory-formed bystander T cells in a relapsed/refractory diffuse large B-cell lymphoma patient. The 804.5 KB PDF, authored by Yuya Masuda and published under CC-BY-4.0 on figshare in April 2026, analyzes T-cell responses before and after CD19 CAR-T cell therapy following CD20 bispecific antibody therapy. It specifically examines the patient's immune response to adenoviral hemorrhagic cystitis, an uncommon complication.

Use Cases

• Analyzing the phenotypic changes in bystander T-cell populations based on the described shift from effector memory to central/effector memory cells.
• Comparing memory T-cell responses and viral infection outcomes based on the described difference between bispecific antibody therapy and CAR-T cell therapy.
• Investigating the relationship between immunotherapy sequencing and antigen-specific T-cell responses based on the described patient timeline.

Strengths

• The data is a detailed, peer-reviewed case report focusing on a specific and uncommon clinical complication.
• It provides a longitudinal analysis of T-cell phenotypes over an 8-week period after pausing therapy, as mentioned in the description.
• The dataset is openly available under a permissive CC-BY-4.0 license.

Limitations

• The dataset is a single-patient case report (n=1), which limits statistical power and generalizability.
• Row count and column-level documentation are absent; data structure must be inferred from the narrative PDF.
• The 804.5 KB file size indicates a very limited scope, likely containing the report text and possibly limited supplementary figures.

Provenance

Source

figshare

Collection Method

Clinical case report from a patient treated with sequential immunotherapies.

Freshness

Last updated 2026-04-22 09:50:42.