Case Report: Endothelial-Targeted Therapy for TTP-Like iMCD-TAFRO

A 2026 case report authored by Jing Du details the clinical presentation, diagnosis, and management of a 20-year-old woman with fulminant idiopathic multicentric Castleman disease (iMCD-TAFRO). The report describes a TTP-like syndrome with severe ADAMTS13 deficiency, outlining a bridging therapy bundle and subsequent targeted anti-IL-6 treatment. The dataset is a 3.8 MB ZIP file containing supplementary materials for this published medical case.

Use Cases

• Analyze clinical presentation patterns based on described symptoms like thrombocytopenia, anasarca, and fever.
• Study therapeutic interventions based on the described bundle of plasma exchange, corticosteroids, and anisodamine.
• Investigate diagnostic challenges based on the described overlap with sepsis, lymphoma, and thrombotic microangiopathy.
• Examine treatment outcomes based on the described use of siltuximab and subsequent relapse with pulmonary hypertension.

Strengths

• Case report includes specific laboratory values, such as ADAMTS13 activity at 5.41%.
• Provides a detailed narrative of clinical management from presentation to one-year follow-up.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• Row count and column-level documentation are unknown, limiting suitability assessment.
• Data is a single case report, which may not be representative for broader statistical analysis.
• The 3.8 MB file size suggests a small-scale dataset.

Provenance

Source

figshare, authored by Jing Du.

Collection Method

Clinical case documentation.

Time Range

Covers a clinical case with one-year follow-up; specific dates not provided.

Freshness

Last updated 2026-03-18 07:40:03.

Geography

Geographic coverage is not specified.