Hypereosinophilic Syndrome Case Report with Eosinophil and IgE Data

A 19.7 KB case report details a 49-year-old man with hypereosinophilic syndrome initially misdiagnosed as atopic dermatitis. The document includes specific clinical measurements such as an absolute eosinophil count of 5.29 × 10⁹/L and total IgE exceeding 6,000 IU/mL. Authored by Huan Li and shared under CC BY 4.0, it describes the patient's 10-year history, treatment response, and subsequent diagnosis of peripheral neuropathy.

Use Cases

• Analyze the correlation between marked eosinophilia (5.29 × 10⁹/L) and severe pruritus in hypereosinophilic syndrome.
• Review the clinical timeline from refractory pruritus to the recognition of sensory-predominant axonal polyneuropathy via nerve conduction studies.
• Examine the treatment efficacy of upadacitinib and mepolizumab on eosinophil levels and neuropathic symptoms.
• Study the quantitative intraepidermal nerve fiber density (IENFD) finding within the age-adjusted reference range, indicating preserved small-fiber integrity.

Strengths

• Includes precise laboratory values like absolute eosinophil count (5.29 × 10⁹/L) and total IgE (>6,000 IU/mL).
• Provides a detailed 10-year patient history and treatment response timeline.
• Document is licensed under the permissive CC BY 4.0 license for reuse.

Limitations

• The dataset is a single case report (n=1), limiting statistical generalizability.
• Data is presented in a narrative DOCX format, not a structured, machine-readable table.
• Contains no columnar data or sample records for automated analysis.

Provenance

Source

figshare, authored by Huan Li.

Collection Method

Clinical case report documenting patient diagnosis and treatment.

Time Range

Covers a 10-year patient history, with report publication in 2026.

Freshness

Last updated on 2026-03-25.