Case Report: Anti-NF155–Positive Demyelination Syndrome Presenting as Optic Neuritis

A single, biopsy-proven case report of a young male patient with combined central and peripheral demyelination (CCPD). The report details a rare presentation where severe optic neuritis was the initial manifestation, and the patient tested positive for anti-neurofascin 155 (anti-NF155) antibodies. Authored by Yujing Peng and shared under a CC-BY-4.0 license on figshare in May 2026, the document is 1013.7 KB in size.

Use Cases

• Training NLP models to identify rare disease presentations based on detailed clinical narrative.
• Studying the correlation between anti-NF155 antibodies and specific neurological symptoms described in the report.
• Benchmarking information extraction systems for clinical features like histopathological findings and antibody test results.
• Supporting medical education on the diagnostic importance of antibody testing in cases of concomitant neuropathy.

Strengths

• Documented case is biopsy-proven, providing a histopathological confirmation of the diagnosis.
• Report highlights a specific and rare antibody (anti-NF155) associated with the condition.
• Shared under a permissive CC-BY-4.0 license, allowing for reuse and analysis.

Limitations

• Contains only a single case report, offering a sample size of one.
• Row count and column-level data are unknown; the primary content is unstructured clinical text.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare, authored by Yujing Peng.

Collection Method

Likely a documented clinical case from medical practice.

Freshness

Last updated 2026-05-22 06:10:11; freshness should be verified.