Supplementary File 1: CCR1+ Monocyte Data for Bronchopulmonary Dysplasia Research

Single-cell transcriptomic data from normal and BPD mouse lungs identifies CCR1+ monocytes as a key upregulated myeloid subpopulation. The study, authored by Yingjuan Geng and shared under CC-BY-4.0, further validates findings in human BPD blood and identifies downstream factors S100A8 and MMP8. This 107.7 KB PDF file was last updated on May 1, 2026.

Use Cases

• Identify dysregulated immune cell populations in bronchopulmonary dysplasia based on single-cell transcriptomic data.
• Validate murine model findings in human clinical samples based on flow cytometry analysis of CCR1+ monocytes.
• Investigate molecular pathways like NF-κB and AKT in monocytes based on their regulation of S100A8 and MMP8 production.
• Explore potential clinical biomarkers for BPD based on the expression of S100A8 and MMP8 in CCR1+ monocytes.

Strengths

• Data integrates findings from mouse models and human clinical samples, including flow cytometry and serum analysis.
• The dataset is associated with a specific mechanistic study linking CCR1+ monocytes to S100A8 and MMP8 via NF-κB and AKT pathways.
• It is shared under a permissive CC-BY-4.0 license for reuse.

Limitations

• The dataset is very small at 107.7 KB, suggesting limited raw data or a summary document.
• Column-level documentation is absent; field semantics must be inferred from the accompanying PDF article.
• Row count is unknown, which may limit suitability assessment for large-scale computational analysis.

Provenance

Source

figshare

Collection Method

Likely contains processed results from single-cell RNA sequencing and flow cytometry experiments.

Freshness

Last updated 2026-05-01 04:16:22; freshness should be verified.