Supplementary File 1: Cdk5 Modulation of Orofacial Pain Signaling

Rodrigo Sandoval's research data from 2026 investigates the role of Cyclin-dependent kinase 5 in purinergic receptor-mediated pain. The dataset likely contains results from calcium imaging in trigeminal neurons and behavioral assays in mice. Findings indicate Cdk5 modulates pain by influencing P2X2/3 receptor kinetics without affecting membrane expression.

Use Cases

• Analyze calcium transient kinetics in trigeminal neurons based on the described fast and slow response patterns.
• Model the relationship between Cdk5 activity and pain behavior based on the described knockout mouse experiments.
• Investigate purinergic receptor signaling modulation based on the described pharmacological and genetic interventions.

Strengths

• Data is associated with a specific, peer-reviewed research hypothesis on Cdk5 and P2X receptors.
• The description details multiple experimental methods including calcium imaging, surface biotinylation, and in vivo behavioral tests.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 1.8 MB file size suggests a relatively small dataset.

Provenance

Source

Rodrigo Sandoval via figshare

Collection Method

Data was generated through laboratory experiments including calcium imaging in cultured neurons and behavioral evaluation in mice.

Freshness

Last updated 2026-05-04 05:32:10