Supplementary file 1_CEBPD may function as a molecular indicator of fibrotic severity and

A supplementary research document analyzing the role of the CEBPD gene in uterine leiomyoma (ULM) fibrosis. The analysis includes transcriptional profiles from two independent ULM cohorts (GSE64763, GSE95101) and single-cell RNA sequencing data. The document was authored by Ran Duan and last updated on 2026-05-19.

Use Cases

• Identify potential diagnostic biomarkers for uterine leiomyoma based on CEBPD expression analysis.
• Study the correlation between gene expression and epithelial-mesenchymal transition (EMT) progression in fibrotic tissue.
• Analyze cellular distribution of gene expression within the tumor microenvironment using single-cell RNA sequencing data.
• Validate histological findings from clinical specimens through immunofluorescence staining results described in the document.

Strengths

• Analysis is based on two independent ULM cohorts (GSE64763, GSE95101), suggesting validation across sources.
• Reports specific diagnostic performance metrics, including AUC values of 0.878 and 0.858 for CEBPD.
• Includes single-cell RNA sequencing data identifying 8 cell subsets in the ULM microenvironment.
• Provides specific correlation results (p < 0.001) between CEBPD and fibrotic mediators like COL1A1, COL1A2, COL3A1.

Limitations

• The dataset is a single 810.0 KB DOCX file, which is a very small supplementary document rather than a primary data repository.
• Row count and column-level documentation for any underlying data are unknown, limiting suitability assessment.
• The actual data files (e.g., raw expression matrices) are not described as being included; the document likely contains analysis and results.

Provenance

Source

figshare

Collection Method

Analysis of public transcriptional profiles (GSE64763, GSE95101) and single-cell RNA sequencing data, validated with clinical specimen staining.

Freshness

Last updated 2026-05-19 05:38:36; freshness should be verified.