Cerebrovascular-CSF Coupling Measurements for Brain Aging and Alzheimer's Disease

A study dataset from 2026 containing physiological measurements from 69 participants (26 healthy young adults, 27 healthy older adults, and 16 early-stage Alzheimer's disease patients). Data was collected using two-channel broadband near-infrared spectroscopy (2bbNIRS) to measure hemoglobin and cerebrospinal fluid dynamics in the prefrontal cortex over 7-minute intervals. The dataset, authored by Fiza Saeed and shared under a CC-BY-4.0 license, quantifies cerebrovascular-CSF coupling across infraslow frequency bands.

Use Cases

• Comparing cerebrovascular-CSF coupling strength between healthy and Alzheimer's disease groups based on the group classifications provided.
• Investigating age-related trends in physiological coupling based on measurements from young adult, older adult, and patient cohorts.
• Developing machine learning models for early Alzheimer's disease detection based on the described HbT-CSF coupling signal features.
• Validating non-invasive measurement techniques for glymphatic system function based on the described broadband near-infrared spectroscopy (bbNIRS) methodology.

Strengths

• Includes data from three distinct participant groups (n=69 total) enabling comparative analysis.
• Describes a specific, non-invasive measurement technique (two-channel broadband near-infrared spectroscopy) for a novel physiological marker.
• Reports statistically significant findings, such as stronger HbT-CSF coupling in the AD group across all frequency bands.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is stored in a DOCX file format (1.5 MB), which may require extraction of underlying data tables.

Provenance

Source

figshare

Collection Method

Data was collected using two-channel broadband near-infrared spectroscopy (2bbNIRS) on human participants.

Freshness

Last updated 2026-05-01 05:27:21; freshness should be verified.