Supplementary File 1: Chemically Induced Homing of Extracellular Vesicles in Mice

Aditya Bansal's supplementary file from a 2026 figshare upload describes research on altering the biodistribution of systemically administered extracellular vesicles (EVs). The study used positron emission tomography imaging of 89Zr-labeled EVs in BALB/c mice to explore how substances like phenothiazine and poly(ethylene) glycol affect EV trafficking. The findings suggest a method to direct EVs to extrahepatic tissues without genetic or chemical modifications.

Use Cases

• Analyzing the effect of subcutaneous chemical injections on systemic EV accumulation based on PET imaging data
• Comparing biodistribution patterns of EVs from various sources mentioned in the description
• Investigating the timing relationship between adjuvant administration and EV trafficking
• Modeling site-specific enhancement of EV delivery for therapeutic applications based on phenothiazine analog findings

Strengths

• Dataset is associated with a specific, peer-reviewed research methodology using 89Zr-labeled EVs and PET imaging
• Research context is clearly described, involving BALB/c mouse models and specific chemicals (phenothiazine, poly(ethylene) glycol)
• License is clearly stated as CC-BY-4.0, allowing for reuse

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The 480.2 KB size suggests the dataset's scope is limited, likely containing summary or supplementary data rather than raw images

Provenance

Source

Aditya Bansal via figshare

Collection Method

Positron emission tomography imaging of 89Zr-labeled EVs in BALB/c mice following subcutaneous chemical injections

Freshness

Last updated 2026-05-14 05:30:08; freshness should be verified