Supplementary file 1_Chinese herbal formulas as adjuncts to antihistamines in chronic spon

50 randomized controlled trials involving 5,814 patients were analyzed using Bayesian and frequentist network meta-analyses to compare the efficacy, recurrence, and safety of second-generation antihistamines alone or combined with classical traditional Chinese medicine formulas for chronic spontaneous urticaria. The dataset, authored by Haiying Lv and last updated on 2026-04-22, contains results from this systematic review, including primary outcomes based on the Symptom Score Reducing Index (SSRI) and secondary outcomes for recurrence and adverse events. The analysis was registered with PROSPERO (CRD420251022634).

Use Cases

• Ranking treatment efficacy for chronic urticaria based on Symptom Score Reducing Index (SSRI) outcomes mentioned in the description
• Comparing recurrence rates of different antihistamine and herbal formula combinations as described in the results
• Assessing the safety profile of adjunctive traditional Chinese medicine therapies based on reported adverse event data
• Conforming sensitivity analyses on study quality and prescription modifications as outlined in the methods

Strengths

• Analysis is based on 50 randomized controlled trials, providing a substantial evidence base
• Includes data from 5,814 patients, offering a meaningful sample size for meta-analysis
• Employs both Bayesian and frequentist network meta-analysis methods for robust statistical comparison
• Risk of bias was assessed using RoB 2.0 and evidence certainty was evaluated with the CINeMA framework

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The overall certainty for safety outcomes was reported as relatively low in the source analysis

Provenance

Source

figshare

Collection Method

Systematic review and network meta-analysis of published randomized controlled trials

Freshness

Last updated 2026-04-22 05:49:23; freshness should be verified