CKAP2L in Endometrial Cancer: Protein Expression and Signaling Pathway Analysis

A 411.7 KB supplementary file from a research study on Cytoskeleton-associated protein 2-like (CKAP2L) in endometrial cancer. The study, authored by Min Wei and published on figshare under CC-BY-4.0, analyzes CKAP2L's role in promoting cancer progression via the PI3K/AKT pathway. It includes results from bioinformatics, immunohistochemistry, and in vitro/in vivo experiments.

Use Cases

• Validate CKAP2L as a biomarker for endometrial cancer based on immunohistochemistry data mentioned in the description
• Study the relationship between CKAP2L expression and clinical features using the bioinformatics approaches described
• Model the PI3K/AKT signaling pathway activation based on the Western blotting and ubiquitination assay results
• Investigate the impact of CKAP2L on cell proliferation and apoptosis using the colony formation and flow cytometry data referenced

Strengths

• Includes data from multiple experimental methods: bioinformatics, immunohistochemistry, Western blotting, and in vivo mouse models.
• The underlying research provides mechanistic insights into CKAP2L's role via ubiquitination and PI3K/AKT signaling.
• Available under a permissive CC-BY-4.0 license for reuse.

Limitations

• The dataset is a single 411.7 KB PDF file, which is a very limited scope for direct computational analysis.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Generated from laboratory experiments including bioinformatics analysis, immunohistochemistry, Western blotting, and in vivo mouse models.

Freshness

Last updated 2026-05-20 05:46:00; freshness should be verified.