Clinical and Biological Impact of Caffeine Therapy in Premature Infants

325 premature neonates were studied to evaluate caffeine citrate therapy for apnea of prematurity. The prospective observational study, authored by Adela-Valeria Neamțu, compared outcomes between groups with high, normal, and no caffeine serum concentrations. Results indicated major complications like intracranial hemorrhage (5.33%) and convulsions followed by death (4.00%) in the caffeine group.

Use Cases

• Modeling adverse event risk based on serum caffeine citrate titer levels mentioned in the description
• Analyzing clinical outcomes for premature infants receiving pulmonary ventilation versus caffeine therapy
• Studying the relationship between drug concentration and complications like intracranial hemorrhage
• Supporting research into individualized therapeutic management for apnea of prematurity

Strengths

• Includes data from 325 premature neonates, providing a substantial clinical cohort.
• Reports specific complication rates, such as 5.33% intracranial hemorrhage and 4.00% convulsions followed by death.
• Prospective observational design suggests a structured data collection process.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect temporal or institutional bias inherent to the single study source.

Provenance

Source

Adela-Valeria Neamțu via figshare

Collection Method

Prospective observational clinical study

Freshness

Last updated 2026-05-13 05:56:37; freshness should be verified.