Supplementary file 1_Clinical evidence of exercise intervention in improving adults with t

33 mechanistic studies and 20 randomized controlled trials (RCTs) are synthesized in this narrative literature review by Xiuli Mo, last updated in May 2026. It explores overlapping pathophysiological pathways and the efficacy of multicomponent exercise and resistance training for elderly patients with type 2 diabetes mellitus (T2DM) and frailty. The document is available as a 181.7 KB DOCX file under a CC-BY-4.0 license on figshare.

Use Cases

• Identify common pathophysiological mechanisms between T2DM and frailty based on the review of inflammaging, insulin resistance, and mitochondrial impairment.
• Evaluate the effectiveness of multicomponent exercise interventions based on synthesized evidence from 20 RCTs.
• Assess the role of resistance training in improving insulin sensitivity and muscle synthesis based on described GLUT-4 and Akt/mTOR pathways.

Strengths

• Synthesizes evidence from 33 mechanistic studies and 20 randomized controlled trials.
• Focuses on a specific clinical population: elderly patients with type 2 diabetes and frailty.
• Explicitly details overlapping pathophysiological pathways such as inflammaging and insulin resistance.

Limitations

• The dataset is a single 181.7 KB document, representing a very limited scope of raw data.
• Row count and column-level documentation are absent; the content is a narrative review rather than structured data.
• Freshness should be verified as the last update date is in the future (2026-05-07).

Provenance

Source

figshare, authored by Xiuli Mo.

Collection Method

Literature review searching PubMed and China National Knowledge Infrastructure (CNKI).

Freshness

Last updated 2026-05-07 04:45:27; freshness should be verified.