Thai Kratom Alkaloid Profiles and Genotypes from Eight Accessions

Eight Mitragyna speciosa (kratom) accessions from Central and Southern Thailand were analyzed for genotypic variation and alkaloid composition. Targeted UPLC-MS profiling quantified 17 monoterpene indole and oxindole alkaloids across young and mature leaves, with mitragynine reaching up to 1.19% w/w in mature leaves. The dataset, authored by Katherine E. Ransden and last updated in May 2026, provides a framework for breeding and metabolic engineering of pharmacologically significant compounds.

Use Cases

• Modeling the relationship between leaf developmental stage and alkaloid stereoisomer distribution (3R vs 3S MIAs) based on the described chemotype patterns.
• Comparing genotypic haplotypes, defined by polymorphisms in MatK and trnH-psbA loci, against phenotypic leaf morphology traits.
• Identifying biosynthetic pathway intermediates, such as strictosidine detected exclusively in juvenile leaves, for metabolic engineering studies.
• Analyzing the consistency of mature leaf alkaloid profiles across accessions despite visible differences in leaf vein coloration.

Strengths

• Quantifies 17 specific alkaloids with precise concentrations (e.g., mitragynine up to 1.19% w/w) across leaf developmental stages.
• Includes genotypic authentication data from four DNA barcoding loci (ITS, rbcL, MatK, trnH-psbA) for eight distinct plant accessions.
• Explicitly compares alkaloid composition between juvenile and mature leaves, revealing stage-dependent biosynthetic shifts.

Limitations

• Row count is unknown, which may limit suitability assessment for large-scale statistical modeling.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data is limited to eight accessions from two regions of Thailand, which may not represent the full genetic diversity of the species.

Provenance

Source

figshare, authored by Katherine E. Ransden.

Collection Method

Targeted metabolite profiling via UPLC-MS and DNA barcoding of plant accessions.

Time Range

null

Freshness

Last updated 2026-05-04 05:30:34; freshness should be verified.

Geography

Central and Southern Thailand