Supplementary file 1_Comparative effectiveness and clinical credibility of nurse-implement

Lili Zhang's supplementary file contains the systematic review and network meta-analysis of 39 randomized trials involving 11,946 participants. The analysis compares the effectiveness of nurse-implementable sedation strategies for mechanically ventilated adults in intensive care, focusing on ventilator-free days. The file was last updated on 2026-05-20 and is shared under a CC-BY-4.0 license.

Use Cases

• Replicate or validate the network meta-analysis results based on the described 39-trial dataset.
• Study the comparative effectiveness of protocolised sedation versus daily sedation interruption based on the reported outcomes.
• Analyze the structure and credibility of evidence in a 17-node intervention network as described in the methods.
• Assess risk of bias and certainty of evidence using the reported RoB 2 and CINeMA frameworks.

Strengths

• Analysis is based on a harmonized dataset of 39 randomized trials with 11,946 participants.
• Reporting follows established PRISMA 2020 and PRISMA-NMA guidelines.
• The review is registered with PROSPERO (CRD420261303518).

Limitations

• The primary data file is a DOCX document; column-level data structure and raw trial data are not directly accessible.
• Row count for the underlying trial data is unknown, which may limit suitability assessment.
• Description metadata is limited; actual data quality and completeness require manual inspection after download.

Provenance

Source

figshare

Collection Method

Systematic review and network meta-analysis of published randomized trials.

Time Range

Temporal coverage of the included trials is not specified.

Freshness

Last updated 2026-05-20 05:24:17; freshness should be verified.

Geography

Spatial coverage of the included trials is not specified.