Supplementary file 1_Complement-mediated ADCP as a distinct and finite cytotoxic mechanism

A 16.1 KB supplementary document from a 2026 study by Carly M. Van Wagoner, published on figshare. The data likely contains quantitative measurements from live-cell imaging experiments comparing Fcγ receptor-dependent and complement-dependent antibody-mediated phagocytosis in primary mouse macrophages. The findings establish complement-mediated ADCP as a distinct and finite cytotoxic mechanism for monoclonal antibodies.

Use Cases

• Modeling the kinetics of complement-mediated phagocytosis based on the described temporal dynamics.
• Comparing the capacity and exhaustion behavior of Fcγ and complement ADCP pathways based on the described functional framework.
• Investigating additive effects on target cell clearance when both phagocytic pathways are engaged simultaneously.

Strengths

• Data is derived from primary mouse macrophages, a physiologically relevant model system.
• Study uses quantitative live-cell imaging and genetic disruption for direct pathway comparison.
• Published under a permissive CC-BY-4.0 license for reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is a 16.1 KB DOCX file, indicating a very limited scope, likely containing summary data or figures rather than raw experimental data.

Provenance

Source

Carly M. Van Wagoner via figshare.

Collection Method

Quantitative live-cell imaging of primary mouse macrophages with genetic and pharmacological pathway modulation.

Time Range

The study was published in 2026, but the specific experimental time range is not stated.

Freshness

Last updated 2026-04-13 05:48:23; freshness should be verified.

Geography

Spatial coverage is not specified.